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thermo-responsive biodegradable paste  (Thermo Fisher)


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    Structured Review

    Thermo Fisher thermo-responsive biodegradable paste
    Thermo Responsive Biodegradable Paste, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/thermo-paste/thermo+responsive+biodegradable+paste/pm39666995-292-63-63
    Average 90 stars, based on 1 article reviews
    thermo-responsive biodegradable paste - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Control:

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste cumulatively released 46.0 ± 12.9% of amikacin vs. 27.4 ± 4.1% of PEG paste and maintained active concentrations against P. aeruginosa for 4 days ( b).

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste has a low viscosity at room temperature (20 °C) and gels at body temperature (37 °C) which allows for the easy application and subsequent conversion to a more viscous state, in contrast with other previously developed chitosan pastes with high inherent viscosity and difficult injection [ , ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste formulation should be further researched with extending antibiotic elution time and efficacy, as well as improving in vitro and in vivo biocompatibility.

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: The viability of cells exposed to thermo-paste exceeded ISO 10993-5 standards with approximately 73% relative viability of a control chitosan sponge.


    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste may provoke a lower inflammatory response compared to PEG paste due to the neutralizing effect of β-GP and the incorporation of neutralized chitosan [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste eluted active concentrations of vancomycin and amikacin for at least 3 days, which would provide protection from invading pathogens during initial management of complex open musculoskeletal wounds [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste and PEG paste demonstrated a higher degradation rate compared to the control sponge at each time point ( p < 0.0001).

    Formulation:

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste cumulatively released 46.0 ± 12.9% of amikacin vs. 27.4 ± 4.1% of PEG paste and maintained active concentrations against P. aeruginosa for 4 days ( b).

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste has a low viscosity at room temperature (20 °C) and gels at body temperature (37 °C) which allows for the easy application and subsequent conversion to a more viscous state, in contrast with other previously developed chitosan pastes with high inherent viscosity and difficult injection [ , ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste formulation should be further researched with extending antibiotic elution time and efficacy, as well as improving in vitro and in vivo biocompatibility.

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: The viability of cells exposed to thermo-paste exceeded ISO 10993-5 standards with approximately 73% relative viability of a control chitosan sponge.


    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste may provoke a lower inflammatory response compared to PEG paste due to the neutralizing effect of β-GP and the incorporation of neutralized chitosan [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste eluted active concentrations of vancomycin and amikacin for at least 3 days, which would provide protection from invading pathogens during initial management of complex open musculoskeletal wounds [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste and PEG paste demonstrated a higher degradation rate compared to the control sponge at each time point ( p < 0.0001).

    In Vitro:

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste cumulatively released 46.0 ± 12.9% of amikacin vs. 27.4 ± 4.1% of PEG paste and maintained active concentrations against P. aeruginosa for 4 days ( b).

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste has a low viscosity at room temperature (20 °C) and gels at body temperature (37 °C) which allows for the easy application and subsequent conversion to a more viscous state, in contrast with other previously developed chitosan pastes with high inherent viscosity and difficult injection [ , ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste formulation should be further researched with extending antibiotic elution time and efficacy, as well as improving in vitro and in vivo biocompatibility.

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: The viability of cells exposed to thermo-paste exceeded ISO 10993-5 standards with approximately 73% relative viability of a control chitosan sponge.


    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste may provoke a lower inflammatory response compared to PEG paste due to the neutralizing effect of β-GP and the incorporation of neutralized chitosan [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste eluted active concentrations of vancomycin and amikacin for at least 3 days, which would provide protection from invading pathogens during initial management of complex open musculoskeletal wounds [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste and PEG paste demonstrated a higher degradation rate compared to the control sponge at each time point ( p < 0.0001).

    In Vivo:

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste cumulatively released 46.0 ± 12.9% of amikacin vs. 27.4 ± 4.1% of PEG paste and maintained active concentrations against P. aeruginosa for 4 days ( b).

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste has a low viscosity at room temperature (20 °C) and gels at body temperature (37 °C) which allows for the easy application and subsequent conversion to a more viscous state, in contrast with other previously developed chitosan pastes with high inherent viscosity and difficult injection [ , ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste formulation should be further researched with extending antibiotic elution time and efficacy, as well as improving in vitro and in vivo biocompatibility.

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: The viability of cells exposed to thermo-paste exceeded ISO 10993-5 standards with approximately 73% relative viability of a control chitosan sponge.


    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste may provoke a lower inflammatory response compared to PEG paste due to the neutralizing effect of β-GP and the incorporation of neutralized chitosan [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste eluted active concentrations of vancomycin and amikacin for at least 3 days, which would provide protection from invading pathogens during initial management of complex open musculoskeletal wounds [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste and PEG paste demonstrated a higher degradation rate compared to the control sponge at each time point ( p < 0.0001).

    Inhibition:

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste cumulatively released 46.0 ± 12.9% of amikacin vs. 27.4 ± 4.1% of PEG paste and maintained active concentrations against P. aeruginosa for 4 days ( b).

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste has a low viscosity at room temperature (20 °C) and gels at body temperature (37 °C) which allows for the easy application and subsequent conversion to a more viscous state, in contrast with other previously developed chitosan pastes with high inherent viscosity and difficult injection [ , ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste formulation should be further researched with extending antibiotic elution time and efficacy, as well as improving in vitro and in vivo biocompatibility.

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: The viability of cells exposed to thermo-paste exceeded ISO 10993-5 standards with approximately 73% relative viability of a control chitosan sponge.


    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste may provoke a lower inflammatory response compared to PEG paste due to the neutralizing effect of β-GP and the incorporation of neutralized chitosan [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste eluted active concentrations of vancomycin and amikacin for at least 3 days, which would provide protection from invading pathogens during initial management of complex open musculoskeletal wounds [ ].

    Article Title: Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
    Article Snippet: Thermo-paste and PEG paste demonstrated a higher degradation rate compared to the control sponge at each time point ( p < 0.0001).



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